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Jeffrey MacDonald (25 To Life, S06E11)


GettyImages
The Zodiac Killer case is still regarded as unsolved to this day, with numerous copycats emerging throughout the years.
One of these cases served as the inspiration for the episode Omnivore, which introduced the recurring serial killer George Foyet, also known as the Boston Reaper.
The manner in which Foyet conducted his initial murders bore a striking resemblance to the Zodiac Killer's modus operandi.
It was during the course of investigating this connection that Hotch unfortunately made a fatal realization, resulting in the tragic loss of his wife.
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